The child can prevent liver cancer if he makes a new search

The drug partially imitates the effect of the child.

Liver congestion often develops into chronic inflammation of the liver and can potentially cause liver cancer. Researchers from the German Cancer Research Center (DKFZ) and the University of Tübingen have shown that children can halt this progress with an intermittent 5:2 program. This children's regimen reduces the incidence of cancer in liver cancer that has existing liver inflammation. Scientists have discovered two proteins in liver cells that play a crucial role in protecting the child. In addition, it was found that an approved drug can partially reproduce its effect.

Chronic heart disease is non-alcoholic liver disease. It can avoid the consequences of the grave: if it is not affected, it can cause inflammation of the liver (steatohepatitis associated with a metabolic disorder, MASH), cirrhosis of the liver and, at the same time, cancer of the liver. Stationary hepatitis is considered a direct consequence of childbirth. It was not in Europe and America that received huge cash prizes in recent decades; Health status is also a plus and a plus in emergencies like India and China. As a result, the number of cases of liver and liver cancer and liver cancer is increasing in the affected countries.

“The core of poor nutrition, obesity, foie inflammation and foie cancer is associated with important restrictions and advice for those affected and also represents a significant toll on health systems.” », explains Mathias Heikenwälder, DKFZ and University Tübingen. “We don't know whether simple changes to the food allow this process to occur exactly.” »

The child who had a temporary déjà eté was dismantled in more than 10 years as a greater effectiveness to lose time and attenuate certain metabolic disorders. Heikenwälder's team focused on the wound, although this approach could also protect against the threat of degeneration and chronic inflammation.

The resistance to ignition of the foie is independent of the heat input

The animals were fed a rich, successful diet that was consistent with the typical western nutritional regime. A group of sours has constant access to food. As before, these animals came out of the body and developed chronic inflammation of the goose liver.

The other group's conditions are not two days a week in the crèche (5:2 or 5:2 in deduction, respectively), but they were authorized before the crèche while waiting for other days. The diet is high in calories, these animals do not cost more, there are few signs of foie diseases and has a high level as well as biomarqueur properties in liver lesions. In short, I have no opposition to the development of MASH.

Since it is important that resistance to the development of stationary hepaticity is independent of total calorie intake, animals can withdraw their rations immediately after the end of the juvenile period.

When experimenting with different variants of the child, it was found that additional parameters determine the protection against the inflammation of the foie: the number and duration of the child's cycles, which plays a role, until the beginning of the child's phase. A régime alimentaire 5:2 functionne mieux qu'un régime 6:1 ; The 24 hour phases are better than the 12 hour phases. A special diet in Malsaine is required for frequent cycles of the regime.

Heikenwälder's team had apparently discovered the molecular context of their child's reaction. At this end, the researchers compare the composition of the protea, the metabolic processes and the activity of the genes in the acidic foie de souris at the beginning and not at the beginning. Two key players responsible for the protective response to them have emerged: the transcription factor PPARα and the enzyme PCK1. The two molecular agents work together to enhance grass acid breakdown and gluconogenesis, preventing grass accumulation.

“Children's cycles involve profound changes in metabolic processes caused by the effective detoxification mechanisms and support in the fight against MASH,” explains Heikenwälder, summarizing the molecular details.

The study of tissue samples from MASH patients is based on the fact that these relationships do not represent a unique phenomenon in the study: here too, the researchers found the same molecular scheme with a reduction in PPAR and PCK1. Are PPAR and PCK1 responsible for your child's beneficial effects? Because both proteins were genetically inactivated at the same time in the liver cells of the stomach, the child was unable to intermittently prevent chronic inflammation or fibrosis.

Pémafibrate, a drug that mimics the action of PPARα in the cell. Can the substance also mimic the protective effect of the child? I'm looking for information regarding this question. The substance contains certain positive changes in the metabolic situation, which were observed with a child 5:2. However, it cannot replicate some of the effects it has on the child. “We are not overwhelmed because we cannot be influenced by one of the two actors equipped with the permafibrate.” “Malheureusement, il n'existe pas encore de medication imitating the effects of the PCK1,” explains Mathias Heikenwälder.

The intermittent child is hepatic therapy

That's why Heikenwälder and his team focus on the effects that their child temporarily has on their health.The prevention of MASH, they were studied during the regimen 5:2 and could also feel the chronic inflammation of the liver.

At this end, the team examined the people who were able to develop MASH after a month of successful and successful government. After four months of additional child separation 5:2 (with the same regimen), these animals were compared with a group that was not with the child. For me, the best sanguine, hepatitis and goose liver inflammation are as good as possible, and in addition, they are less developmentally impaired than goose liver cancer and have few cancer occurrences in the goose liver region.

“It is important to us that the child 5:2 has great potential – to protect against MASH and liver cancer, even if chronic inflammation of the liver is diagnosed,” sums up the sought-after director Heikenwälder. “The results that justify the patient examinations can determine whether the child is protected against the chronic inflammation of the liver that also occurs during treatment.” »

Why is a degree required for these experiences?

A high-calorie, balanced diet and a sedentary lifestyle contribute to increasing the proportion of overweight people in many regions of the world. The health condition also increases the risk of a whole range of secondary diseases for those touched, reporting cardiovascular disease, metabolic disorders, cancer and articular problems. Understanding these connections and ideas represents an extremely important goal for the search.

Additional organs and systems are associated with the development of health consequences associated with health. The foie, the pancreas, the cervix, the lymphatic organs and the adipex tissue work in this ensemble, which cannot be simulated in the culture box. The gut may also play a role in the development of MASH. The spontaneous development of foie gras cancer on the part of a diseased liver cannot be recapitulated and studied when all these involved facts are present.

The influence of immune cells that migrate from the periphery of the body to the foie gras and that are active in the body and remigrate, or that interact with adipose tissue, is crucial. It may not be an intact organism. The on-site experience is also necessary to record the duration of children's periods in order to obtain better results in the context of the daily rhythm (day/night).

The 5:2 youth regime is the most popular. It is believed to be easy to incorporate into daily life as children's days may be adjusted to personal needs and certain foods may not be an option. “Néanmoins, il y aura toujours of gens qui ne pourront pas suivre a strict à long terme,” explained Heikenwälder. “We are continuing to look for drug combinations that we can use to improve the protective effects for children.” »