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There are the best hours that others have to reveal tumors

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medicineThere are the best hours that others have to reveal tumors

A team from the United States has discovered that our cells have different levels of immunity during the journey and that they participate in the competition.

The CAR-T cells, created in the laboratory to attack tumors, showed their ineffectiveness at certain moments of the day and their greatest effectiveness at other moments.

The CAR-T cells, created in the laboratory to attack tumors, showed their ineffectiveness at certain moments of the day and their greatest effectiveness at other moments.

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In 2022, the search team supervised by Christoph Scheiermann from the Universities of Geneva and Munich observed an unsupervised phenomenon: the increase and severity of tumors are subject to a daily rhythm (not 24-hour rhythm) of immunized cells. “To exploit these results in a clinical context, we need to grapple with the details of a model and reality,” he says.

For this reason, scientists injected melancholic tumor cells into a group of patients, then the tumor was already injected at different moments of the day, two weeks and later. Just an hour, then the animal's immune activation, the amount of immunized cells, but also the cell type and their characteristics are taken into account.

Cela can make the diagnosis fausser

This discovery has no impact on the clinic schedule. “In the hospital, a biopsy is effective because it detects tumor diseases and their immune characteristics,” says Christoph Scheiermann, professor at the Department of Pathology and Immunology and at the Research Center for Inflammation at the Faculty de médecine de l'UNIGE.

“The characteristics, particularly the immunotherapy, were specifically decided on the basis of this test.” Or, depending on the biopsy time, the number of infiltrated immune cells could be very high and the tumor could be classified as “rough” or “strès faible”, and the Tumor was “froide”, so it would crash la meme tumeur. It is enough that the biopsy is performed at a specific time to run the risk of diagnostic error.

The results are very different over the next week

To get even closer to the reality clinic, scientists are managed by their groups of two approved and most commonly used features: CAR-T cells (created for measurement to enable elucidation and to combat the specific proteins of tumor cells identify) There are inhibitions at the checkpoints that complement the system's natural immunity and enhance anti-tumor activation. “Managed at the moment, these characteristics have not achieved any result.” “A la bonne heure, la charge tumorale diminuait de manière très significant,” detailed Christoph Scheiermann.

“The number of immunized cells is not present or close to the tumor, but only due to their characteristics and behavior that they have to shed.” Since the modulation of molecular elements is maintained to generate these characteristics, the moment when our administrators differ from this, crucially important. Good moment, the combat cells will resume immediately. At another moment, the molecules may not have exploded and the drug had no effect.

The matinal treatment is plus efficace

These studies have been updated and discussed in the review “Cell”. They were confirmed by examining patient survival testing in the suite of these immunotherapies. A maternity protection (maximum immunity to human behavior) is a system associated with one of the best survivors. The studies are part of a project that has been evaluated because of the problems that arise from the impact of a change in exam hours and studies.

Other projects will specialize in potential drugs that can only be estimated. The main implications of these findings on immune defense rhythms are: from the point of view of the medical staff, they can adapt the therapeutic approaches to a transient disease profile (between 10 and 20% of the natural sex affecting a biological rhythm). replaced by rapport with the general population, and they will not be without consequences for other pathologies, especially autoimmune diseases.

(Comm./MP)